The CELLTRACKS® AUTOPREP® System enables automated and standardized complex sample processing using immunomagnetic cell capture and fluorescence staining of rare cells. CELLTRACKS® technology was developed to capture rare cells efficiently and reproducibly. The ferrofluid reagents are target-specific antibodies conjugated to nanomagnetic particles to isolate rare cells from whole blood. The ferrofluid/sample mixture is placed in a strong magnetic field, which causes the immunomagnetically labeled target cells to move to the side of the tube. The CELLTRACKS® System aspirates the blood and resuspends the cells in a smaller volume of buffer. The enrichment steps are repeated several times.
At the end of the process, the cells are permeabilized and stained with fluorescent reagents, then dispensed into the cartridge, ready for scanning.
Intact cells and fragments are enriched, but cells are not permeabilized or stained. Scientists can process these samples off-line using a variety of molecular diagnostic tools.
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procedures. Last updated on: 22 April 2013